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Cameron Poe is a highly decorated military officer who is sent to prison because of killing a man while defending his wife. Seven years later, he is granted a parole. He is put on a plane with many other convicts. Everything looks smooth until one of the convicts, Cyrus “The Virus” Grissom breaks out of his restraints and takes control of the plane. The D.E.A quickly learns of the event and plans on shooting the plane down, but U.S. Marshall Vince Larkin sees Poe as an ally and tries to work with him before his superiors shoot down the plane.